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Dr Clare Morrison

Article by Dr Clare Morrison

Levitra Vs Cialis: A Detailed Comparison


Levitra and Cialis are two brand-name medications available to treat erectile dysfunction, which affects 50% of men over the age of 40 at some point in their lives.

There are many similarities between these two erectile dysfunction drugs, but also some differences. For example, Cialis 36-hour is longer-lasting than Levitra; but Levitra can work more quickly than Cialis.

Here’s a chart looking at the key differences between them:

Levitra Cialis
MedExpress Price From £37 From £40
Prescription required? Yes Yes
Active ingredient Vardenafil Tadalafil
Dosage Available in 5, 10 and 20mg tablets Available in 2.5, 5, 10 and 20mg tablets
How fast does it work? Can work in just 15 minutes, though normally takes effect within 30 minutes Can take anywhere between 30 minutes to two hours to work
How long does it last? Effects can last up to five hours Effects can last up to 36 hours
How to take May be taken with or without food May be taken with or without food. Be careful to avoid taking with greasy or high-fat meals, or eating or drinking grapefruit, as this can affect how the drug works
Selling point Can be effective very quickly, and may be used as an alternative to Viagra Is available in lower doses and is long-lasting – which means you won’t need to time your sexual activity
Common Side effects Facial flushing, headache, indigestion, and a stuffy or runny   nose Facial flushing, headache, indigestion, and a stuffy or runny nose

How does Levitra work?

Levitra tablets work in the same way as other ED treatments. It contains the active ingredient Vardenafil – a PDE5 inhibitor – which relaxes the muscles in the walls of the blood vessels, increasing the blood flow to your penis. This helps you get harder erections when you’re aroused.

What is Levitra Orodispersible?

Levitra Orodispersible works slightly differently to Levitra oral medication. You take the tablet by placing it on your tongue, where it rapidly disintegrates, and then you swallow it. Levitra Orodispersible tablets must be taken without liquid.

How does Cialis work?

Tadalafil is the active ingredient in Cialis. This generic form is also called Tadalafil. It works similarly to other erectile dysfunction treatments – also acting as a PDE5 inhibitor and increasing blood flow to your penis.

Does Levitra work faster than Cialis?

Levitra usually takes around 30 minutes to take effect – but it can work in as little as just 15 minutes. It should be taken about an hour before it’s needed, whereas Cialis may take up to two hours before it’s effective.

Winner: Levitra

Does Levitra last longer than Cialis?

Most people find that Levitra remains active for around five hours, which means it helps you get an erection within this period when you experience sexual stimulation. However, the duration of action with Cialis may be up to 36 hours – that’s eight times longer than Viagra. This is why it’s often referred to as ‘the weekend pill’. Levitra tends to be less affected by food or alcohol, so it can be taken with meals.

Winner: Cialis

Does Levitra have fewer side effects than Cialis?

Potential side effects for both Levitra and Cialis are almost identical. These include:

  • Facial flushing
  • Stuffy or runny nose
  • Back/head/muscle pain
  • Migraines
  • Indigestion
  • Feeling and/or being sick
  • Blocked or runny nose
  • Vision disturbances

Always let your doctor know if you’re taking other drugs and decide to take erectile dysfunction medication so you can avoid potential interactions. If you experience severe side effects like chest pain, allergic reactions or an irregular heartbeat, seek medical attention.

Winner: Draw

Levitra vs Cialis: Which is better?

If you’re looking for an erectile dysfunction treatment with a quicker onset, which remains active for 4-6 hours, Levitra is a great choice.

Cialis, on the other hand, is a longer-lasting treatment for erectile dysfunction that can help you have more spontaneous sexual activity. Its effects last up to 36 hours, which creates a larger window for you to get an erection when you’re aroused.

Both treatments are also available as generic medications — Tadalafil (Cialis) and Vardenafil (Levitra) — at a lower price.

Find out what treatment is suitable for you on our website.

Dr Clare Morrison
Dr Clare Morrison
Experienced General Practitioner in Hampshire since 1995, with particular interest in Nutrition, Obesity and Smoking Cessation.
Originally published December 15 2017, updated May 01 2024